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I just installed PTC creo parametric for education and I am running windows 10 (if that helps at all). My mouse left and right click do not work when modeling so I cannot pan or right click on anything. My scroll wheel also does not work. I can rotate the objects but not zoom in or out. I would greatly appreciate your help. Thanks.
Windows 10 is not yet officially supported for any versions of Creo, however, you can see this thread for information on the mouse wheel. Not sure about the buttons.